Vision: The Consortium on Translational Research in the Microbiome (CTRM) is a community of practice focused on facilitating the implementation of microbiome research to enhance drug discovery and development.
By focusing upon harmonization of emerging enabling technologies, we provide a collaborative platform for knowledge sharing and consensus building.
Who We Are: The CTRM was established in 2017 through mutual interests in the human microbiome and the professional connections of the Institute for Life Science Entrepreneurship at Kean University in New Jersey, the Office of Research at the City University of New York and the Westchester Biotech Project.
Each individual on the committee, and the organizations they represent, appreciate the clinical potential of research on the human microbiome. And, each wants to work collaboratively in the development of enabling technologies and know-how, as a basis for the translation of scientific findings into effective medical breakthroughs.
Finally, all of us are dedicated to accelerating the discovery and development of new treatments to ensure better health and address unmet needs.
Below you can find Microbiome Research resources related to reproducibility, challenges in standardization, and the growing awareness that it is an essential moment for developing consensus.
Feel free to send us your favorites as well.
Virtual Roundtable: Building Data Infrastructure for Microbiome Research
May 30, 2019 • Recording • PDF
Virtual Roundtable: Standardization, CTRM
October 16, 2018 • Recording
ATCC Update - Presentation PDF
Organizations Leading the Way
The International Human Microbiome Consortium: IHMC
The International Metagenomics and Microbiome Standards Alliance (IMMSA)
NIH Human Microbiome Project (HMP)
NIH Integrative Human Microbiome Project (iHMP)
National Institute of Standards and Technology (NIST)
- NIST (PDF Overview): Microbiome and Metagenomic Standards
- NIST: Microbiome Community Measurements
- NIST: Microbial Genomic Measurements
Institute for Life Science Entrepreneurship
American Type Culture Association
American Food Project - American Gut
Articles, Publications, and Events
Below are a list of recent publications relevant to the microbiome, along with those used in the Literature Review attached to our Consortium on Translational Research in the Microbiome Overview Document.
2019 Article: The Human Microbiome Project expands the toolbox for studying host and microbiome interactions (NIH)
2019 Event: Microbiome Movement – Drug Development Summit
2019 Event: 2019 NIST Workshop on Standards for Microbiome Measurements (NIST)
2019 Article: Drug Companies and Doctors Battle Over the Future of Fecal Transplants (NY Times)
2019 Paper: Improving End-User Trust in the Quality of Commercial Probiotic Products. (Frontiers in Microbiology)
2019 Paper: In Fimo: A Term Proposed for Excrement Examined Experimentally (AGA Institute)
2018 Paper: Interrogating the microbiome: experimental and computational considerations in support of study reproducibility (Drug Discovery Today)
2018 Paper: The human gut microbiome in early-onset type 1 diabetes from the TEDDY study (Nature)
2018 Paper: Temporal development of the gut microbiome in early childhood from the TEDDY study (Nature)
2017 Paper: 2017 NIH-wide workshop report on “The Human Microbiome: Emerging Themes at the Horizon of the 21st Century” (Microbiome)
2016 Event: 2016 NIST Standards for Microbiome Measurements Workshop Recordings (NIST)
Useful Review Papers
Awany D, et al. (2019) Host and Microbiome Genome-Wide Association Studies Current State and Challenges. Front. Genet. 9:637. doi: 10.3389/fgene.2018.00637
Andrea C. Wong, Maayan Levy (2019) New Approaches to Microbiome-Based Therapies. mSystems4: e00122-19. doi: 10.1128/mSystems.00122-19
Surana NK (2019) Moving Microbiome Science from the Bench to the Bedside, a Physician-Scientist Perspective. mSystems4: e00160-19. doi: 10.1128/mSystems.00160-19
D'Argenio V (2018) Human Microbiome Acquisition and Bioinformatic Challenges in Metagenomic Studies. International Journal of Molecular Sciences. 19(2). pii: E383. doi: 10.3390/ijms19020383
Duvallet C (2018) Meta-analysis generates and prioritizes hypotheses for translational microbiome research. Microbial Biotechnology. 11(2):273-276. doi: 10.1111/1751-7915.13047
Gundogdu A, Nalbantoglu U (2017) Human Genome-Microbiome Interaction: Metagenomics Frontiers for the Aetiopathology of Autoimmune Diseases. Microbial Genomics. 3(4):e000112. doi: 10.1099/mgen.0.000112
Clavel T, Lagkouvardos I, Stecher B (2017) From Complex Gut Communities to Minimal Microbiomes via Cultivation. Current Opinion in Microbiology. 38:148-155. doi: 10.1016/j.mib.2017.05.013
Mimee M, Citorik RJ, Lu TK (2016) Microbiome Therapeutics – Advances and Challenges. Advanced Drug Delivery Reviews. 105(Pt A):44-54. doi: 10.1016/j.addr.2016.04.032
Jovel J, Patterson J, Wang W, et al. (2016) Characterization of the Gut Microbiome Using 16S or Shotgun Metagenomics. Frontiers in Microbiology. 7:459. doi: 10.3389/fmicb.2016.00459
Sung J, Hale V, Merkel AC, Kim P-J, Chia N (2016) Metabolic Modeling with Big Data and the Gut Microbiome. Applied & Translational Genomics. 10:10-15. doi: 10.1016/j.atg.2016.02.001
Nguyen TLA, Vieira-Silva S, Liston A, Raes J (2015) How Informative is the Mouse for Human Gut Microbiota Research? Disease Models & Mechanisms. 8(1):1-16. doi: 10.1242/dmm.017400